In 1828, at the request of then St. Louis Bishop Joseph Rosati, four sisters set out from their Motherhouse in Emmitsburg, Maryland, in September to journey to St. Louis. Bishop Rosati requested the sisters to take charge of a hospital. When the sisters arrived, they found an expanding city and many in need of health care. The sisters established the first hospital west of the Mississippi River; today, it is known as DePaul Hospital. The sisters then began to serve in education and in needed social ministries. Mental health, care for orphans, and schools for the needy were opened and staffed.