| Parish Name | Opened | Closed | Mergers or Building razed |
| Annunciation - St. Louis City | 1861 | 1951 | Building demolished in 1951. |
| Ascension / St. Paul - Normandy | 1947 | 2008 | Ascension and St. Paul (Pine Lawn) merged in 1995 to form Ascension/St. Paul, which closed in 2008. |
| Assumption - Herculaneum | 1916 | 2016 | |
| Assumption - Perryville | 1817 | 1965 | Building demolished. |
| Assumption - St. Louis City | 1861 | 1965 | Building demolished. |
| Corpus Christi - Jennings | 1915 | 2005 | In 2005, the parish merged with St. Lucy to form Holy Name of Jesus Parish. |
| Good Shepherd - Ferguson | 1958 | 2005 | In 2005, Blessed Teresa of Calcutta was formed by merging Good Shepherd, Sts. John & James, St. Bartholomew, and St. Sebastian. |
| Holy Angels / Our Lady of the Angels - Kinloch | 1931 | 2002 | In 2002, the property was donated to the City of Kinloch for a Museum and learning center, the church demolished. |
| Holy Cross - St. Louis City | 1863 | 1993 | Our Lady of Mount Carmel and Holy Cross merged to form Our Lady of the Holy Cross in 1993. |
| Holy Family - St. Louis City | 1898 | 2005 | |
| Holy Ghost - Berkeley | 1923 | 1999 | |
| Holy Ghost - St. Louis City | 1879 | 1962 | Visitation and Holy Ghost merged in 1961 to form Visitation-Holy Ghost. It was renamed Visitation in 1975. |
| Holy Guardian Angels - St. Louis City | 1866 | 1991 | |
| Holy Innocents - St. Louis City | 1854 | 2005 | |
| Holy Trinity - St. Ann | 2002 | 2020 | 3500 St. Luke Lane |
| Immaculate Conception - St. Mary | 1874 | 2018 | |
| Immaculate Conception - St. Louis City | 1854 | 1977 | In 1977, St. Henry merged with Immaculate Conception to form Immaculate Conception/St. Henry. |
| Immaculate Conception / St. Henry - St. Louis City | 1977 | 2005 | In 1977, St. Henry merged with Immaculate Conception to form Immaculate Conception/St. Henry. |
| Mary, Queen of the Universe - Lemay | 1955 | 2003 | The church became the chapel for St. Mark school. |
| Most Blessed Sacrament - St. Louis City | 1908 | 2001 | |
| Most Holy Name of Jesus - St. Louis City | 1865 | 1992 | In 1992, Our Lady of Perpetual Help, Most Holy Name, St. Liborius and Most Holy Trinity merged into the Most Holy Trinity location. |
| Most Holy Rosary - St. Louis City | 1891 | 1994 | In 1994, St. Engelbert and Most Holy Rosary merged to form St. Elizabeth Mother of John the Baptist. |
| Most Holy Trinity (Slovak) - St. Louis City | 1898 | 1982 | . |
| Most Precious Blood - St. Louis City | 1961 | 2003 | |
| Nativity of the Blessed Virgin Mary - Belgique | 1884 | 1992 | |
| Nativity of Our Lord - St. Louis City | 1904 | 1982 | |
| North American Martyrs - Florissant | 1955 | 2005 | |
| Notre Dame de Lourdes - Wellston | 1902 | 1992 | In 1992, the parish of St. Augustine was formed by merging Notre Dame, St. Barbara, St. Mark, St. Rose and St. Edward. |
| Our Lady Help of Christians - St. Louis City | 1900 | 1975 | Building demolished in 1975. |
| Our Lady of Covandago - St. Louis City | 1915 | 1932 | |
| Our Lady of Czestochowa - St. Louis City | 1906 | 1957 | Building demolished in 1957. |
| Our Lady of Fatima - Florissant | 1950 | 2005 | In 2005, St. Philippine Duchesne Parish was formed by merging St. Dismas, Our Lady of Fatima and St. Thomas the Apostle. |
| Our Lady of Good Counsel - Bellefontaine Neighbors | 1951 | 2005 | |
| Our Lady of Good Counsel - St. Louis City | 1894 | 1950 | Parish moved to Bellefontaine Neighbors, MO. |
| Our Lady of Loretto - Spanish Lake | 1959 | 2005 | In 2005, the parish of Our Lady of the Rosary was formed by merging Our Lady of Loretto (Spanish Lake) St. Aloysius (Spanish Lake) and a portion of Transfiguration. |
| Our Lady of Mercy - Hazelwood | 1964 | 2005 | |
| Our Lady of Mount Carmel - St. Louis City | 1871 | 1993 | Our Lady of Mount Carmel and Holy Cross merged to form Our Lady of the Holy Cross in 1993. |
| Our Lady of Perpetual Help - St. Louis City | 1874 | 1992 | A fire destroyed the church in 1987. In 1992, Our Lady of Perpetual Help, Most Holy Name, St. Liborius and Most Holy Trinity merged into the Most Holy Trinity location. |
| Our Lady of the Rosary - Claryville | 1874 | 1963 | |
| Our Lady of the Rosary - Spanish Lake | 2005 | 2016 | Our Lady of the Rosary Parish was formed in 2005, with the merger of Our Lady of Loretto, St. Aloysius (Spanish Lake) and a small portion of Transfiguration (Florissant) parishes. |
| Sacred Heart of Jesus - St. Louis City | 1871 | 1978 | The building was destroyed by fire in 1986. |
| Simon of Cyrene - St. Louis City | 1993 | 2005 | Simon of Cyrene was formed from the merger of St. Philip Neri and St. Adalbert parishes in 1993. |
| St. Adalbert - St. Louis City | 1912 | 1993 | St. Adalbert and St. Philip Neri merged to form Simon of Cyrene in 1993. |
| St. Agnes - St. Louis City | 1891 | 1993 | |
| St. Aloysius - Spanish Lake | 1908 | 2005 | In 2005, the parish of Our Lady of the Rosary was formed by merging Our Lady of Loretto (Spanish Lake) St. Aloysius (Spanish Lake) and a portion of Transfiguration. |
| St. Aloysius Gonzaga - St. Louis | 1892 | 2005 | The buildings were demolished. |
| St. Ann - St. Louis City | 1897 | 1992 | In the summer of 1992 it was merged with Visitation-Holy Ghost. |
| St. Ann Shrine (Visitation) - St. Louis City | 1995 | 2016 | |
| St. Augustine - St. Louis City | 1874 | 1982 | |
| St. Barbara - St. Louis City | 1893 | 1992 | In 1992, the parish of St. Augustine was formed by merging Notre Dame, St. Barbara, St. Mark, St. Rose and St. Edward. |
| St. Bartholomew - Hazelwood | 1959 | 2005 | In 2005, Blessed Teresa of Calcutta was formed by merging Good Shepherd, Sts. John & James, St. Bartholomew, and St. Sebastian. |
| St. Bernard - St. Louis City | 1874 | 1973 | The building was razed for highway construction. |
| St. Blaise - St. Louis City | 1961 | 2004 | In 2004 St. Blaise and St. Lawrence (Bridgeton) merged to form Holy Spirit Parish. |
| St. Bonaventure - St. Louis City | 1871 | 1883 | Building was demolished. |
| St. Boniface - Perryville | 1869 | 1964 | Building was demolished. |
| St. Boniface - St. Louis City | 1860 | 2005 | |
| St. Bridget of Erin - St. Louis City | 1853 | 2003 | |
| St. Casimir - Hathaway Manor | 1956 | 1992 | |
| St. Casimir - St. Louis City | 1889 | 1955 | Building was razed for highway construction. |
| St. Catherine of Alexandria - Riverview | 1958 | 2005 | |
| St. Catherine of Siena - Pagedale | 1921 | 2005 | |
| St. Charles Borromeo - St. Louis City | 1903 | 1982 | Buildings were demolished. |
| St. Christopher - Florissant | 1967 | 2005 | |
| St. Columbkille - Byrnesville | 1880 | 1957 | |
| St. Columbkille - St. Louis City | 1872 | 1952 | |
| St. Dismas - Florissant | 1957 | 2005 | In 2005, St. Philippine Duchesne Parish was formed by merging St. Dismas, Our Lady of Fatima and St. Thomas the Apostle. |
| St. Dominic Savio | 1956 | 2018 | In 2018, St. George and St. Dominic Savio merged to form St. John Paul II Parish. |
| St. Edward - St. Louis City | 1893 | 1992 | In 1992, the parish of St. Augustine was formed by merging Notre Dame, St. Barbara, St. Mark, St. Rose and St. Edward. |
| St. Elizabeth - St. Louis City | 1873 | 1951 | The parish was suppressed by Cardinal Ritter to encourage racial integration. |
| St. Engelbert - St. Louis City | 1891 | 1994 | In 1994, St. Engelbert and Most Holy Rosary merged to form St. Elizabeth Mother of John the Baptist. |
| St. Frances Xavier Cabrini - Jennings | 1965 | 1999 | |
| St. Francis De Sales - St. Louis City | 1867 | 2005 | In 2005 it closed as a parish and was reopened as an oratory run by the Institute of Christ the King Sovereign Priest. |
| St. George - Affton | 1915 | 2018 | In 2018, St. George and St. Dominic Savio merged to form St. John Paul II Parish. |
| St. Gregory - St. Ann | 1942 | 2002 | |
| St. Hedwig - St. Louis City | 1904 | 2005 | |
| St. Henry - St. Louis City | 1885 | 1977 | In 1977, St. Henry merged with Immaculate Conception to form Immaculate Conception/St. Henry. |
| St. Jerome - St. Louis City | 1952 | 2005 | |
| St. John Nepomuk - St. Louis City | 1854 | 2005 | Closed as a parish in 2005 and reopened as a chapel. They still retain the sacramental registers. |
| St. John the Evangelist - Lithium | 1904 | 1985 | |
| St. Joseph - St. Louis City | 1844 | 1979 | It was closed in 1979 and reclassified as a shrine. |
| St Joseph National Lithuanian - St. Louis City | 1915 | 1970 | |
| St. Kevin - St. Ann | 1953 | 2002 | |
| St. Kevin - St. Louis City | 1876 | 1904 | |
| St. Lawrence O'Toole - St. Louis City | 1855 | 1948 | Building was demolished. |
| St. Lawrence the Martyr - Bridgeton | 1960 | 2004 | Building was demolished. |
| St. Leo - St. Louis City | 1888 | 1978 | Building was demolished. |
| St. Liborius - St. Louis City | 1856 | 1992 | In 1992, Our Lady of Perpetual Help, Most Holy Name, St. Liborius and Most Holy Trinity merged into the Most Holy Trinity location. |
| St. Louise de Marillac - Jennings | 1935 | 1999 | |
| St. Lucy - St. Louis City | 1957 | 1998 | In 2005, the parish merged with Corpus Christi to form Holy Name of Jesus Parish. |
| St. Malachy - St. Louis City | 1858 | 1959 | Building was demolished. |
| St. Mark - St. Louis City | 1893 | 1992 | In 1992, the parish of St. Augustine was formed by merging Notre Dame, St. Barbara, St. Mark, St. Rose and St. Edward. |
| St. Mary of Victories - St. Louis City | 1860 | 2005 | Closed as a parish in 2005 and reopened as a chapel. |
| St. Mary's - Bridgeton | 1851 | 2001 | Building was demolished. |
| St. Michael - St. Louis City | 1849 | 1975 | |
| St. Patrick - St. Louis Convention Center | 1981 | 2009 | |
| St. Patrick - University City | 1940 | 2001 | The parish closed in 2001 and is now St. Andrew Kim Catholic Church. |
| St. Patrick - St. Louis City (6th and Biddle) | 1843 | 1973 | Building was demolished. |
| St. Paul the Apostle - Pine Lawn | 1909 | 1995 | Ascension and St. Paul (Pine Lawn) merged in 1995 to form Ascension/St. Paul, which closed in 2008. |
| St. Paul - St. Louis City | 1909 | 1995 | |
| St. Peter Claver - Kinloch | 1916 | 1956 | |
| St. Philip Neri - St. Louis City | 1919 | 1993 | St. Adalbert and St. Philip Neri merged to form Simon of Cyrene in 1993. |
| St. Pius X - Glasgow Village | 1954 | 2005 | |
| St. Rose of Lima - St. Louis City | 1884 | 1992 | In 1992, the parish of St. Augustine was formed by merging Notre Dame, St. Barbara, St. Mark, St. Rose and St. Edward. |
| St. Sebastian - St. Louis City | 1953 | 2005 | In 2005, Blessed Teresa of Calcutta was formed by merging Good Shepherd, Sts. John & James, St. Bartholomew, and St. Sebastian. |
| St. Stanislaus Kostka - St. Louis City | 1880 | 2005 | Due to a schism in 2005, the parish was canonically suppressed and is not affiated with the Roman Catholic Church. |
| St. Stephen of Hungary - St. Louis City | 1934 | 1957 | |
| St. Teresa of Avila - St. Louis City | 1885 | 2003 | |
| St. Thomas More - Bel Ridge | 1957 | 1999 | |
| St. Thomas of Aquin - St. Louis City | 1882 | 2005 | |
| St. Thomas the Apostle - Florissant | 1960 | 2005 | In 2005, St. Philippine Duchesne Parish was formed by merging St. Dismas, Our Lady of Fatima and St. Thomas the Apostle. |
| St. Timothy - St. Louis City | 1958 | 2003 | |
| St. William - Woodson Terrace | 1953 | 2002 | |
| Sts. John and James - Ferguson | 1882 | 2005 | In 2005, Blessed Teresa of Calcutta was formed by merging Good Shepherd, Sts. John & James, St. Bartholomew, and St. Sebastian. |
| Sts. Mary and Joseph - St. Louis City | 1821 | 2005 | Closed as a parish in 2005 and reopened as a chapel. |
| Transfiguration - Florissant | 1965 | 2005 | In 2005, the parish of Our Lady of the Rosary was formed by merging Our Lady of Loretto (Spanish Lake) St. Aloysius (Spanish Lake) and a portion of Transfiguration. |
| Visitation/St. Ann - St. Louis City | 1992 | 2016 | Visitation merged with Holy Ghost in 1961 to form Visitation-Holy Ghost. It was renamed Visitation in 1975. In 1992, it merged with St. Ann Parish and Shrine to form Visitation/St. Ann Shrine. |